The Parametric and Non-parametric Bootstrap Resamplings for the Visual Acuity Measurement

We propose a useful tool for the visual acuity measurement from the results of parametric and non-parametric bootstrap algorithms in the logistic regression model. We present the kurtosis and the variance of deviance residuals to estimate the efficiency of bootstrap resampling. We applied our parametric and non-parametric algorithms to the problem of the visual acuity measurement and obtained the efficiency measures for the comparison of the parametric and non-parametric bootstrap resamplings

Psychophysical Threshold Estimates in Logistic Regression Using the Bootstrap Resampling

We propose the non-parametric bootstrap resampling algorithm for the problem of psychophysical threshold estimates. We use the logistic regression with guessing rate and the log-likelihood ratio test statistics of two samples for testing the hypothesis by using the bootstrap resampling. We apply our algorithm to the visual acuity test, and show that the bootstrap resampling is useful for the problem of the two-sample test when the numbers of observations are not identical between the two samples. We also propose the bootstrap algorithm for one-sample testing to certify the values of parameters and threshold obtained by logistic regression

A statistical modelling of the visual acuity measurement and its multiple test procedure

To establish the computer assisted system of the visual acuity test, we propose a statistical modelling of the visual acuity measurement and its multiple test procedure. The psychometric functions for individual patients are produced by the logistic regression combined with the guessing rate. We adopt test statistics based on (i) psychometric functions (the Cochran-Mantel-Haenszel method) and (ii) psychophysical thresholds (the delta method). The multiple comparisons are performed by the step-down procedure with Ryan-Einot-Gabriel-Welsch (REGW) significance levels. To show the practical effectiveness of our system, we present a numerical example of four patient groups

Novel adsorptive type apheresis device Immunopure for ulcerative colitis from clinical perspectives based on clinical trials : Japan and Europe.

Several adsorptive type devices for ulcerative colitis are used for the induction of remission in patients with active severe disease worldwide. In 2020, the novel apheresis device Immunopure for ulcerative colitis was launched in Japan. Immunopure, like the polyethylene terephthalate column, uses polyarylate, a type of polyester resin, as the adsorbent. Similar to the cellulose acetate column, Immunopure is filled with adsorbent beads and expected to provide ease of use, with minimal risk of column clogging. Immunopure adsorbs leukocytes and platelets, especially activated platelets and platelet-leukocyte aggregates. In this article, the capability of Immunopure is evaluated from clinical perspective based on a clinical trial in Japan/Europe. As a result, Immunopure is comparable to other products in clinical effectiveness and indicated for the treatment of patients with refractory moderate ulcerative colitis, making it highly useful in clinical practice

Functional MRIを用いた視中枢および眼球運動中枢の研究

科学研究費補助金研究成果報告書研究種目: 基盤研究(B)研究期間: 1996～1998課題番号: 08457463研究代表者: 西田 保裕（滋賀医科大学・医学部・講師）研究分担者: 可児 一孝（滋賀医科大学・医学部・教授）研究分担者: 稲富 昭太（滋賀医科大学・医学部・名誉教授）研究分担者: 永田 啓（滋賀医科大学・医学部・講師）研究分担者: 中村 二郎（滋賀医科大学・医学部・助手）研究分担者: 青木 佳子（滋賀医科大学・医学部・助手）研究分担者: 林 理（滋賀医科大学・医学部・助手）研究分担者: 吉田 健一（滋賀医科大学・医学部・助手

STUDY OF STRABISMUS USING A VIRTUAL REALITY SYSTEM

科学研究費補助金研究成果報告書研究種目: 一般研究(B)研究期間: 1993～1994課題番号: 05454471研究代表者: 可児 一孝（滋賀医科大学・医学部・教授）研究分担者: 山出 新一（滋賀医科大学・医学部・助教授）研究分担者: 西田 保裕（滋賀医科大学・医学部・講師）研究分担者: 永田 啓（滋賀医科大学・医学部・助手）研究分担者: 中村 二郎（滋賀医科大学・医学部・助手）研究分担者: 佐々本 研二（滋賀医科大学・医学部・講師）研究分担者: 稲富 昭太（滋賀医科大学・医学部・名誉教授

A trial manufacturing of a fundus perimeter by which the target automatically pursue eye movement

科学研究費補助金研究成果報告書研究種目: 基盤研究(A)研究期間: 1995～1997課題番号: 07557262研究代表者: 可児 一孝（滋賀医科大学・医学部・教授）研究分担者: 稲富 昭太（滋賀医科大学・医学部・名誉教授）研究分担者: 山出 新一（滋賀医科大学・医学部・助教授）研究分担者: 西田 保裕（滋賀医科大学・医学部・講師）研究分担者: 永田 啓（滋賀医科大学・医学部・講師）研究分担者: 中村 二郎（滋賀医科大学・医学部・助手）研究分担者: 黄野 桃世（滋賀医科大学・医学部・助手）研究分担者: 吉田 健一（滋賀医科大学・医学部・助手）研究分担者: 林 理（滋賀医科大学・医学部・助手）研究分担者: 山田 重喜（滋賀医科大学・医学部・助手